According to a team led by Vadim V. Klimontov, MD, PhD, it was recently suggested that dipeptidyl peptidase (DPP)-4 inhibitors, like linagliptin, reduce renal fibrosis and diabetic nephropathy progression. The researchers observed the drug’s role in any kidney changes. The findings will be displayed in a poster session on June 6 at the American Diabetes Association 75^th Scientific Sessions in Boston, MA.

For 8 weeks, 8-week-old male diabetic mice were treated with 10 mg/kg of linagliptin each day. After analyzing the renal structures with light and electron microscopic images, the team was able to identify the changes.

“The number of podocyte foot processes was increased (p=0.007), and the number of endothelial fenestrae in glomerular capillaries tended to be increased (p=0.1) on linagliptin treatment,” the authors confirmed.

On average the treated mice experienced a 37.4% mesangial expansion, based on fractional mesangial volume. In addition, the medication diminished the width of the basal membrane of the proximal tubules to a great extent.

“The data from the current study demonstrate that DPP-4 inhibitor linagliptin ameliorates renal fibrosis and podocyte injury in a model of type 2 diabetic nephropathy,” the study concluded.

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A public notice posted on one of the side doors of the Dialysis Clinic informs patients that due to problems with its dialysis solutions, treatments are been put on hold at the LBJ Medical Center, in Fagaalu, American Samoa on Friday, June 5, 2015. Residents who require dialysis were in their third day without the vital treatment Friday after a product recall closed their clinic, but so far none have sought emergency medical attention, the U.S. territory's only hospital said. Until Saturday, there are no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii. (AP Photo/Fili Sagapolutele)

PAGO PAGO, American Samoa - American Samoa's only dialysis clinic has reopened after a product recall forced it to close for two days.

LBJ Medical Center said the clinic reopened at 4 p.m. Friday and began treating patients who require dialysis. The clinic shut down Wednesday after the hospital learned of a recall of a solution used in its machines. A fresh supply arrived to the island around 2 p.m. Friday. The clinic had been scheduled to reopen at 1 a.m. Saturday.

Those being treated Friday to Sunday are patients who had appointments scheduled for Wednesday through Saturday. Regularly scheduled appointments are expected to resume Monday.

"Those who came in say that they knew that the cargo flight had landed and decided to come to the hospital — taking their chances that the clinic will open thereafter," said dialysis unit nurse manager Olita Tafiti. "I guess word got out quickly that the shipment did in fact arrive on island."

Tafiti said three dialysis patients admitted themselves to the emergency room early Friday afternoon, and they were the first to get treatment when the clinic opened.

Until Friday, there were no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii.

The recalled solution was from off-island supplier Fresenius Medical Care. Its North American headquarters is in Waltham, Massachusetts.

The recall occurred after sample testing showed the substance — NaturaLyte Liquid Bicarbonate Concentrate — might eventually develop bacteria levels that exceed acceptable limits, Fresenius spokesman Jon Stone said.

The company expedited the shipment of replacement liquid bicarbonate to American Samoa, Stone said.

How long a patient can safely go without dialysis depends on factors such as health condition and age, said Dr. Anjay Rastogi, director the dialysis program at the University of California, Los Angeles.

Generally, patients require the treatment three times a week, with some cases requiring four treatments, Rastogi said. Some patients can go a week without dialysis, but some with no kidney function can go only three or four days, he said.

"The short end of it, it's very time-sensitive," Rastogi said, adding he's especially concerned about those who might not have had dialysis since Monday.

He noted any contamination in the solution used for dialysis could be fatal.

Another shipment is due to arrive Friday night from Honolulu on Hawaiian Airlines, the only carrier connecting American Samoa to the U.S.

Additionally, a U.S. military flight is scheduled to arrive Monday afternoon from Honolulu with the rest of the supplies, Tafiti said.

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Associated Press writer Jennifer Sinco Kelleher in Honolulu contributed to this report.

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PAGO PAGO, American Samoa (AP) — American Samoa's only dialysis clinic has reopened after a product recall forced it to close for two days.

LBJ Medical Center said the clinic reopened at 4 p.m. Friday and began treating patients who require dialysis. The clinic shut down Wednesday after the hospital learned of a recall of a solution used in its machines. A fresh supply arrived to the island around 2 p.m. Friday. The clinic had been scheduled to reopen at 1 a.m. Saturday.

Those being treated Friday to Sunday are patients who had appointments scheduled for Wednesday through Saturday. Regularly scheduled appointments are expected to resume Monday.

"Those who came in say that they knew that the cargo flight had landed and decided to come to the hospital — taking their chances that the clinic will open thereafter," said dialysis unit nurse manager Olita Tafiti. "I guess word got out quickly that the shipment did in fact arrive on island."

Tafiti said three dialysis patients admitted themselves to the emergency room early Friday afternoon, and they were the first to get treatment when the clinic opened.

Until Friday, there were no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii.

The recalled solution was from off-island supplier Fresenius Medical Care. Its North American headquarters is in Waltham, Massachusetts.

The recall occurred after sample testing showed the substance — NaturaLyte Liquid Bicarbonate Concentrate — might eventually develop bacteria levels that exceed acceptable limits, Fresenius spokesman Jon Stone said.

The company expedited the shipment of replacement liquid bicarbonate to American Samoa, Stone said.

How long a patient can safely go without dialysis depends on factors such as health condition and age, said Dr. Anjay Rastogi, director the dialysis program at the University of California, Los Angeles.

Generally, patients require the treatment three times a week, with some cases requiring four treatments, Rastogi said. Some patients can go a week without dialysis, but some with no kidney function can go only three or four days, he said.

"The short end of it, it's very time-sensitive," Rastogi said, adding he's especially concerned about those who might not have had dialysis since Monday.

He noted any contamination in the solution used for dialysis could be fatal.

Another shipment is due to arrive Friday night from Honolulu on Hawaiian Airlines, the only carrier connecting American Samoa to the U.S.

Additionally, a U.S. military flight is scheduled to arrive Monday afternoon from Honolulu with the rest of the supplies, Tafiti said.

___

Associated Press writer Jennifer Sinco Kelleher in Honolulu contributed to this report.

• American Samoa

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This Friday, June 5, 2015 photo shows the entrance to the territorial government owned Fagaalu hospital, the LBJ Tropical Medical Center, in Fagaalu, American Samoa. Residents who require dialysis were in their third day without the vital treatment Friday, after a product recall closed their clinic, but so far none have sought emergency medical attention, the U.S. territory's only hospital said. Until Saturday, there are no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii. (AP Photo/Fili Sagapolutele)

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A public notice posted on one of the side doors of the Dialysis Clinic informs patients that due to problems with its dialysis solutions, treatments are been put on hold at the LBJ Medical Center, in Fagaalu, American Samoa Friday, June 5, 2015. Residents who require dialysis were in their third day without the vital treatment Friday after a product recall closed their clinic, but so far none have sought emergency medical attention, the U.S. territory's only hospital said. Until Saturday, there are no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii. (AP Photo/Fili Sagapolutele)

Share Photo

A public notice posted on one of the side doors of the Dialysis Clinic informs patients that due to problems with its dialysis solutions, treatments are been put on hold at the LBJ Medical Center, in Fagaalu, American Samoa on Friday, June 5, 2015. Residents who require dialysis were in their third day without the vital treatment Friday after a product recall closed their clinic, but so far none have sought emergency medical attention, the U.S. territory's only hospital said. Until Saturday, there are no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii. (AP Photo/Fili Sagapolutele)

PAGO PAGO, American Samoa (AP) — American Samoa's only dialysis clinic has reopened after a product recall forced it to close for two days.

LBJ Medical Center said the clinic reopened at 4 p.m. Friday and began treating patients who require dialysis. The clinic shut down Wednesday after the hospital learned of a recall of a solution used in its machines. A fresh supply arrived to the island around 2 p.m. Friday. The clinic had been scheduled to reopen at 1 a.m. Saturday.

Those being treated Friday to Sunday are patients who had appointments scheduled for Wednesday through Saturday. Regularly scheduled appointments are expected to resume Monday.

"Those who came in say that they knew that the cargo flight had landed and decided to come to the hospital — taking their chances that the clinic will open thereafter," said dialysis unit nurse manager Olita Tafiti. "I guess word got out quickly that the shipment did in fact arrive on island."

Tafiti said three dialysis patients admitted themselves to the emergency room early Friday afternoon, and they were the first to get treatment when the clinic opened.

Until Friday, there were no other options for dialysis patients on the island with a population of about 55,000, roughly 2,300 miles south of Hawaii.

The recalled solution was from off-island supplier Fresenius Medical Care. Its North American headquarters is in Waltham, Massachusetts.

The recall occurred after sample testing showed the substance — NaturaLyte Liquid Bicarbonate Concentrate — might eventually develop bacteria levels that exceed acceptable limits, Fresenius spokesman Jon Stone said.

The company expedited the shipment of replacement liquid bicarbonate to American Samoa, Stone said.

How long a patient can safely go without dialysis depends on factors such as health condition and age, said Dr. Anjay Rastogi, director the dialysis program at the University of California, Los Angeles.

Generally, patients require the treatment three times a week, with some cases requiring four treatments, Rastogi said. Some patients can go a week without dialysis, but some with no kidney function can go only three or four days, he said.

"The short end of it, it's very time-sensitive," Rastogi said, adding he's especially concerned about those who might not have had dialysis since Monday.

He noted any contamination in the solution used for dialysis could be fatal.

Another shipment is due to arrive Friday night from Honolulu on Hawaiian Airlines, the only carrier connecting American Samoa to the U.S.

Additionally, a U.S. military flight is scheduled to arrive Monday afternoon from Honolulu with the rest of the supplies, Tafiti said.

___

Associated Press writer Jennifer Sinco Kelleher in Honolulu contributed to this report.

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