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Paired bacteriophage therapy holds promise against superbugs |
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Live Science: The researchers developed two kinds of phages against E. coli, a bacterium normally found in the human gut. One kind, called the lytic phage, simply killed E. coli. The other kind, dubbed the temperate phage, injected the bacteria with DNA that had two effects: It protected them against the lytic phage, making them 20 times more resistant to its lethal effects, but also disrupted the antibiotic-resistance genes in the microbes, making them sensitive to drugs called carbapenems, which are often the last line of effective antibiotics against resistant bacteria.
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